The wife and I took a ' research vacation ' several years ago. I found several good things and a few bad things about these kinds of trip. The good things are that you will find nice helpful people, access to many genealogy libraries and ( sometimes ) interesting information.
Now the bad side is time and money. Unless your are retired and wealthy, these trips seem to run out of both time and money. While in Bakersfield, VT, we found that the town clerks office was only open for a few hours each day. In New Ipswich,NH, the libary wasn't even open during the week. In Ipswich,MA, we found similar problems. Now on the money side: hotel, food, and gas all cost. So, if you are like me ( middleclass ), there wasn't much to spend.